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Research Indicates Link Between High Sugar Diet and Opioid Addiction

New research from the laboratory of behavioral neuroscience at the University of Guelph has suggested a possible link between diet and risk of opioid addiction. Specifically, children and adults may be more vulnerable to opioid addiction when high amounts of refined sugars are consumed.

There has been a lot of press recently about the current opioid crisis — and for good reason. The Centers for Disease Control and Prevention (CDC) reports that provisional counts for the number of deaths has increased by 21 percent in the period 2015-2016. Drug overdoses are now claiming lives at double the rate of motor vehicle accidents and firearms combined.

Sugar Activates Reward Centers in Brain

Research studies have revealed that refined sugar activates the reward centers in the brain in the same manner as addictive drugs. Opioid abuse has also been linked to poor diet, including a preference for foods that are high in sugar. Based on this link, researchers had questions about whether there was a connection between a diet with an excessive amount of refined sugar and an increased susceptibility to opioid addiction.

How Research Was Conducted

The research team looked at whether an unlimited level of access to high fructose corn syrup changed laboratory rats’ behavior and responses to oxycodone, a semi-synthetic opioid. High fructose corn syrup, a commonly used food additive in North American processed foods and soft drinks, was selected for this study.

In one study conducted by doctoral student Meenu Minhas, the rats were given unrestricted access to drinking water sweetened with high fructose corn syrup. The sweetened water was removed after about a month. After a few days where the rats didn’t have access to any sweetened water, researchers evaluated the rats’ response to oxycodone.

The researchers found that when the rats consumed high levels of corn syrup, they may experience less rewards from the oxycodone. As a result, the rats may be looking to take higher amounts of the drug.

High Sugar Diet May Contribute to Opioid Addiction

The results indicate that a diet high in sugar may dampen the pleasure that someone may get from taking drugs such as Percocet, Percodan, and OxyContin at lower doses. Since these sedative drugs normally make a user feel more relaxed shortly after being ingested, someone who isn’t getting these results is likely to take a larger dose to get the desired results.

Higher doses of sedatives and painkillers can be dangerous. At high levels, they can interfere with central nervous functioning and slow down breathing, leading to coma or respiratory arrest. When combined with alcohol, their effects multiply since alcohol is also a depressant drug.

This research is another good reason to eat a balanced diet, including lean meats, fruits and vegetables, whole grains and low-fat dairy products. There is a place for sweets, but in moderation.