Compound May Offer Pain Relief Without Fear of Addiction

New research from Indiana University-Bloomington may give doctors and their patients living with pain a non-opioid option for treating severe pain.

Researchers conducted a pre-clinical study involving mice. They discovered that compounds known as PAMs (Positive Allosteric Modulators) heighten the effect of natural pain relievers the body produces internally when injured or exposed to stress. PAMs were first discussed with attendees at the 2016 Conference for the Society for Neuroscience, held in San Diego, California.

About PAM

The researchers chose a PAM that would intensify endocannabinoids. These two brain compounds (anandamide and 2-arachidonoylglycerol) specifically act on the CB1 receptor that responds to the presence of THC, the main psychoactive ingredient in marijuana. The PAM used in the study was GAT211, a molecule that coauthor Ganesh Thakur at Northeastern University created that had effects that concentrated on the brain.

The PAM increased the effects of the endocannabinoids without creating the undesired side effects associated with marijuana use. These include lowering of body temperature and clumsiness.

The pain relief achieved from PAM was more effective and lasted longer than when drugs were used that work by breaking down then metabolizing the brain’s cannabis-type compounds. Using PAM on its own means natural painkillers target the correct part of the brain as needed. The alternative is take drugs that bind to receptor sites throughout the body.

Increases the Body’s Natural Ability to Relieve Pain

Study leader Andrea G. Hohmann, a professor and chair of neuroscience at the University’s Department of Psychology and Brain Sciences, stated that the study revealed a PAM increases the body’s pain relieving ability without decreasing effectiveness over time. This is a key component of addiction; a person finds that they need to consume more of their drug of choice to experience the desired effect.

Professor Hohmann went on to say that she sees the research her team is doing as “an important step forward” in the goal to find new, non-addictive pain relievers.

The results of the study were published in the journal Biological Psychiatry.

Non-Addictive Painkillers Help Save Lives from Opioid Overdose

Continuing to find ways of providing pain relief for patients that don’t involve drugs with a high potential for abuse is of utmost importance in the battle against opioid addiction. Tens of thousands of lives are now lost each year due to overdoses and millions of people are abusing these drugs.

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